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Pulmonary embolism (PE) is the main cause of in-hospital demise and the third most frequent cause of cardiovascular demise. The clinical presentation of PE is variable, and choosing the appropriate therapy for individual patients can be difficult. Traditionally, therapy of PE has involved a choice of anticoagulation, thrombolysis or surgical procedure; nonetheless, a spread of percutaneous interventional technologies have been developed which can be underneath investigation in patients with intermediate-high-threat or high-risk PE. These interventional applied sciences include catheter-directed thrombolysis (with or with out ultrasound help), aspiration thrombectomy and combinations of the aforementioned ideas. These interventional remedy options would possibly lead to a extra rapid enchancment in proper ventricular operate and pulmonary and/or systemic haemodynamics particularly patients.